Importance of nutrition in preterm babies
- Introduction...
- 1. Importance of n...
- 2. Learning object...
- 3. Recommended nut...
- 4. Inherent limita...
- 5. The result.......
- 6. Problems associ...
- 7. Increased risk ...
- 8. Increased risk ...
- 9. Osteopenia of P...
- 10. Neuro-developm...
- 11. EUGR & lower f...
- 12. Long term adve...
- 13. In conclusion...
Introduction
DR. JAYASHREE MONDKAR
MD, DM (Neonatology)
Professor & Head
Department of Neonatology
LTMMC and Sion Hospital
Mumbai
1. Importance of nutrition in preterm babies
► Preterm infants are at risk for poor growth while in
NICU and after discharge from the NICU
► Hence special attention should be provided to feeding
of preterm babies soon after birth
2. Learning objectives
► Recommended nutritional goal for preterm babies
► “ Extra Uterine Growth Restriction (EUGR) ”
► Short and long term adverse effects of EUGR
3. Recommended nutritional goal for preterm babies
► Premature infants have greater nutritional needs to achieve
optimal growth in the neonatal period than at any other time
in life
► Extra uterine growth of a preterm baby should parallel the
intrauterine growth trajectory of a fetus of comparable
gestational age
* American Academy of Pediatrics Committee on Nutrition Pediatrics 1985; 75(5): 976 -986
4. Inherent limitations of the preterm baby
► Immaturity
♦ Limited nutrient stores
♦ Immature metabolic pathways & osmolar limitations
♦ Immature GI tract,
♦ Incoordination of suck swallow breathe cycle
► Catabolic effects of illness
♦ Due to associated problems like RDS, sepsis, apnea
► High metabolic needs
♦ Requirement for increased nutrient intake for growth
5. The result....
► Cumulative deficits in protein & energy resulting in slower
growth
► Large proportion of VLBW babies have postnatal growth failure
also called extrauterine growth restriction (EUGR)
► EUGR can be defined as weight <10th centile at 36 weeks
PMA or at discharge
6. Problems associated extra uterine growth restriction
► Short term
♦ Increased risk of retinopathy of prematurity
♦ Chronic lung disease
♦ Poor bone health (osteopenia of prematurity)
► Long term
♦ Blindness due to ROP
♦ Adverse neuro-developmental sequelae
♦ Lower final weight & height at 20 years of age
♦ Adult metabolic syndrome
7. Increased risk of retinopathy of prematurity (ROP)
► Increased risk of type 1 ROP (Severe Type) In extremely low
gestational age newborns if
♦ Intake of total calories, lipids, and carbohydrates in the
first month was in the lowest quartile and gowth velocity
was in the lowest quartile
♦ Improving the early nutrition in very preterm babies may
help prevent development of sight-threatening ROP and
blindness
* Vander Veen DK et al. PLoS One. 2013; 8(5): e64325
8. Increased risk of chronic lung disease
► Chronic lung disease is a common morbidity in smaller preterm
babies, related to ventilation, oxygen toxicity and infection
► Babies with poor nutritional status, especially those with intra
uterine growth restriction are at greater risk for chronic
lung disease
► Chronic lung disease further increases the risk of poor
nutritional status and post natal growth
* Ehrenkranz RA. Pediatr Res 2011
9. Osteopenia of Prematurity
► Suboptimal supplementation of milk with phosphorus, calcium
and vitamin D results in osteopenia of prematurity also called
metabolic bone disease
► This can result in
♦ Increased risk of fractures of long bones and ribs
♦ Poor linear growth and
♦ Failure to wean from the ventilator
10. Neuro-developmental sequelae
► Preterm brain is very vulnerable to undernutrition which
may permanently affect later cognitive attainment
► Lower weight gain is associated withpoor mental development
index, poor psychomotor development index, higher risk
of neurodevelopmental impairment and cerebral palsy
11. EUGR & lower final weight and height
► Long term
♦ VLBW infants are twice as likely to have a height less
than the third percentile at 20 years of age
* Flannery DJ, Schluchter M, et al. Outcomes in young
adulthood for very-low-birth-weight infants.
N Engl J Med 2002; 346:149
12. Long term adverse effects of EUGR
► As adults, EUGR babies are at increased risk for
♦ Coronary heart disease
♦ Type II diabetes mellitus
♦ Hypercholesterolemia
♦ Hypertension
♦ Stroke
*(Barker Br J Obstet Gynaecol 1992; 99: 275-276)
13. In conclusion
► Early enteral nutrition is important for optimal growth of
preterm babies
► Poor nutrition is associated with EUGR
► EUGR causes increased risk of ROP, BPD, Osteopenia
► EUGR also increases the risk of poor ND outcomes